Concepts for aminoglycoside serum level monitoring
نویسندگان
چکیده
منابع مشابه
Fluorescence polarization immunoassay. I. Monitoring aminoglycoside antibiotics in serum and plasma.
Fluorescence polarization immunoassays of the aminoglycoside antibiotics gentamicin, tobramycin, and amikacin in plasma and serum are described and shown to be clinically useful. The aminoglycoside tracers were prepared by reacting the parent compounds with 5-[(4,6-dichlorotriazin-2-yl)-amino] fluorescein. Antisera specific for the compounds were raised in rabbits by conventional procedures. Tr...
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Enzymatic modification results in high-level resistance to aminoglycoside (HLAR), which eliminates the synergistic bactericidal effect of combined exposure to a cell wall-active agent and an aminoglycoside. So aim of the study was to determine prevalence of HLAR enterococcal isolate and to study distribution of aminoglycoside modifying enzyme genes in them. A total of 100 nonrepeat isolates of ...
متن کاملSerum protein binding of the aminoglycoside antibiotics.
The binding of four aminoglycoside antibiotics by human serum was investigated under controlled conditions of physiological pH and temperature, by means of an ultrafiltration technique. No serum binding was demonstrable for gentamicin, tobramycin, or kanamycin, whereas streptomycin was 35% bound. Previous conflicting studies are discussed, and some of the pharmacological implications are consid...
متن کاملChemical assay, involving liquid chromatography, for aminoglycoside antibiotics in serum.
We describe a chemical assay involving "high-pressure" liquid chromatography for the quantitative determination of three aminoglycosides: netilmicin, tobramycin, and gentamicin. The drugs are separated from serum by means of precipitation of the serum proteins with acetonitrile after dilution with a buffer. The aminoglycosides are quantitatively extracted into the supernate, which is further pu...
متن کاملMonitoring of serum gentamicin level in a general hospital.
Gentamicin is an aminoglycoside antibiotic which is commonly used in the treatment ofserious Gram-negative infections. However, gentamicin like other aminoglycosides, has a narrow therapeutic index and is potentially ototoxic and nephrotoxic. Blood levels following administration of gentamicin has been shown to be highly unpredictable and monitoring of gentamicin levels is necessary to ensure e...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1982
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/9.3.168